Crk 抗体
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008].
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Latest Publications for our Crk 抗体
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).: "Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions." in: Proteomics, Vol. 13, Issue 14, pp. 2125-34, (2013) (PubMed).
: "Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation." in: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1582-92, (2009) (PubMed).
: "[Biological roles of signaling adaptor protein CRK]." in: Seikagaku. The Journal of Japanese Biochemical Society, Vol. 81, Issue 5, pp. 361-76, (2009) (PubMed).
: "Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5719-27, (2008) (PubMed).
: "Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4." in: Biochemical and biophysical research communications, Vol. 362, Issue 4, pp. 976-81, (2007) (PubMed).
: "The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase." in: Cellular microbiology, Vol. 9, Issue 10, pp. 2497-516, (2007) (PubMed).
: "Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation." in: Experimental cell research, Vol. 295, Issue 1, pp. 258-68, (2004) (PubMed).
: "Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells." in: The Journal of cell biology, Vol. 166, Issue 2, pp. 225-35, (2004) (PubMed).
: "Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas." in: Oncogene, Vol. 22, Issue 39, pp. 7950-7, (2003) (PubMed).
Aliases for Crk 抗体
Crk oncogene (Crk) 抗体v-crk avian sarcoma virus CT10 oncogene homolog (crk) 抗体
CRK proto-oncogene, adaptor protein (CRK) 抗体
CRK proto-oncogene, adaptor protein (Crk) 抗体
v-crk avian sarcoma virus CT10 oncogene homolog L homeolog (crk.L) 抗体
v-crk sarcoma virus CT10 oncogene homolog (CRK) 抗体
v-crk avian sarcoma virus CT10 oncogene homolog (Crk) 抗体
c-Crk 抗体
CG1587 抗体
CRK 抗体
crk 抗体
Crk-I 抗体
Crk-II 抗体
Crk-III 抗体
crk2 抗体
Crk3 抗体
CRKII 抗体
crkII 抗体
CrkIII 抗体
Crko 抗体
D-CRK 抗体
D-Crk 抗体
DCrk 抗体
Dcrk 抗体
dCRK 抗体
dCrk 抗体
Dmel\\CG1587 抗体
fb34h10 抗体
fc05a01 抗体
fi19g05 抗体
p38 抗体
P38C-CRK 抗体
v-crk 抗体
wu:fb34h10 抗体
wu:fc05a01 抗体
wu:fc54a04 抗体
wu:fi19g05 抗体
zgc:100936 抗体
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