(Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Li, Noah, Noah: "Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication." in: The Journal of general virology, Vol. 92, Issue Pt 8, pp. 1832-42, (2011) (PubMed).
Aliases for CPSF4 抗体
cleavage and polyadenylation specific factor 4 (CPSF4) 抗体 cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) 抗体 cleavage and polyadenylation specific factor 4 (LOC733099) 抗体 cleavage and polyadenylation specific factor 4 (LOC100360200) 抗体 cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S) 抗体 cleavage and polyadenylation specific factor 4 (cpsf4) 抗体 cleavage and polyadenylation specific factor 4 (Cpsf4) 抗体 30kDa 抗体 C79664 抗体 cpsf30 抗体 CPSF30 抗体 nar 抗体 NAR 抗体 neb1 抗体 NEB1 抗体