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Chen, Teramura, Iwata: Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. in Biomaterials 2011
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Lim, Joy, Hill, San Brian Chia: Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease. in European journal of medicinal chemistry 2011
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Human Prothrombin ELISA Kit for Sandwich ELISA - ABIN612790
Badimon, Badimon, Turitto, Vallabhajosula, Fuster: Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. in Circulation 1989
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Mouse (Murine) Prothrombin ELISA Kit for Sandwich ELISA - ABIN2010738
Wang, Braun, Zhang, Norström, Thorlacius: Thrombin generation in abdominal sepsis is Rho-kinase-dependent. in Biochemical and biophysical research communications 2015
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Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (显示 BGN ELISA试剂盒) plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE ELISA试剂盒)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (显示 GP1BA ELISA试剂盒)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (显示 MARK2 ELISA试剂盒) interaction regulated MCP-1 (显示 CPT1B ELISA试剂盒), TF, MCSF (显示 CSF1 ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (显示 SERPINC1 ELISA试剂盒) nanoparticle therapeutics.
Thrombin-PAR1 (显示 F2R ELISA试剂盒) signaling, via nitric oxide and EPCR (显示 PROCR ELISA试剂盒), promotes hematopoietic stem cell (HSC (显示 FUT1 ELISA试剂盒)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (显示 CDC25C ELISA试剂盒) and Ras-associating domains of phospholipase C epsilon (显示 PLCE1 ELISA试剂盒).
Although rare, the prothrombin Belgrade mutation represents strong thrombophilia with early onset of thrombosis in a large Serbian pedigree
There were no significant differences in factor V and factor II genotypes between infertile men and normal controls.
histone H4 has a rapid and drastic inhibitory effect on prothrombin activation by prothrombinase (显示 F10 ELISA试剂盒) that is likely to dominate pathophysiology
prothrombotic mutations in factor V Leiden (显示 F5 ELISA试剂盒) and prothrombin as well as older age are risk factors for venous thrombosis
p300 (显示 EP300 ELISA试剂盒) inhibition attenuates both thrombin induced-CCL2 (显示 CCL2 ELISA试剂盒) expression and histone H3 (显示 HIST3H3 ELISA试剂盒) and H4 acetylation in HLFs, suggesting that p300 (显示 EP300 ELISA试剂盒) is involved in thrombin-induced CCL2 (显示 CCL2 ELISA试剂盒) expression via hyperacetylating histone H3 (显示 HIST3H3 ELISA试剂盒) and H4.
p300 (显示 EP300 ELISA试剂盒)-dependent histone H3 (显示 HIST3H3 ELISA试剂盒) acetylation and C/EBPbeta (显示 CEBPB ELISA试剂盒)-regulated IKKbeta (显示 IKBKB ELISA试剂盒) expression contribute to thrombin-induced IL-8/CXCL8 (显示 IL8 ELISA试剂盒) expression in human lung epithelial cells.
Thrombin, via PAR1 (显示 MARK2 ELISA试剂盒) activation, synergistically augments LPS (显示 IRF6 ELISA试剂盒)-induced Human endometrial endothelial cells production of chemokines involved in immune cell recruitment and survival, suggesting a mechanism by which intrauterine abruption and bacterial infection may together be associated with an aggravated uterine inflammatory response.
Clinical significance of prothrombin G20210A mutation in homozygous patients.
The prevalence of FVL (显示 F5 ELISA试剂盒) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (显示 STXBP1 ELISA试剂盒)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (显示 F5 ELISA试剂盒) mutation with ROP (显示 STXBP1 ELISA试剂盒) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (显示 SULF1 ELISA试剂盒) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (显示 SULF1 ELISA试剂盒) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (显示 MAPK1 ELISA试剂盒), MSK1 (显示 RPS6KA5 ELISA试剂盒), and NF-kappaB (显示 NFKB1 ELISA试剂盒) play important roles in thrombin-induced iNOS (显示 NOS2 ELISA试剂盒) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (显示 F2R ELISA试剂盒)) and thereby increasing the sensitivity of the myofilament to Ca(2 (显示 CA2 ELISA试剂盒)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (显示 UGDH ELISA试剂盒) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (显示 F10 ELISA试剂盒) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (显示 UGDH ELISA试剂盒) and by receptor-mediated up-regulation of factor XIII (显示 UGDH ELISA试剂盒) synthesis
In conclusion, thrombin activates pro-MMP-2 (显示 MMP2 ELISA试剂盒) in the absence of elevated pro-MMP-2 (显示 MMP2 ELISA试剂盒) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (显示 MMP2 ELISA试剂盒)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R ELISA试剂盒), RhoA (显示 RHOA ELISA试剂盒), and myocardin (显示 MYOCD ELISA试剂盒).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA