This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008].
Jin, Shim, Kim, Chae, Chung: "Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders." in: Experimental & molecular medicine, Vol. 41, Issue 5, pp. 354-61, (2009) (PubMed).
Aliases for COTL1 抗体
coactosin like F-actin binding protein 1 (COTL1) 抗体 coactosin-like 1 (Dictyostelium) (Cotl1) 抗体 coactosin-like F-actin binding protein 1 (Cotl1) 抗体 1810074P22Rik 抗体 2010004C08Rik 抗体 CLP 抗体 Clp 抗体