COMP 蛋白
(Cartilage Oligomeric Matrix Protein (COMP))
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].
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Latest Publications for our COMP 蛋白
: "ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas." in: FEBS open bio, Vol. 10, Issue 9, pp. 1856-1867, (2020) (PubMed).: "Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)." in: The Biochemical journal, Vol. 377, Issue Pt 2, pp. 479-87, (2004) (PubMed).
Aliases for COMP 蛋白
cartilage oligomeric matrix protein (COMP) 蛋白cartilage oligomeric matrix protein (sce3551) 蛋白
cartilage oligomeric matrix protein (CJA_1292) 蛋白
cartilage oligomeric matrix protein (Comp) 蛋白
COMP 蛋白
EDM1 蛋白
EPD1 蛋白
MED 蛋白
PSACH 蛋白
THBS5 蛋白
TSP5 蛋白
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