The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].
Albert, Hanzawa, Legtenberg, de Ruwe, van den Heuvel, Collart, Boelens, Timmers: "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex." in: The EMBO journal, Vol. 21, Issue 3, pp. 355-64, (2002) (PubMed).
Albert, Lemaire, van Berkum, Gentz, Collart, Timmers: "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits." in: Nucleic acids research, Vol. 28, Issue 3, pp. 809-17, (2000) (PubMed).