S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Toczydlowska-Socha, Zielinska, Kurkowska, Astha, Almeida, Stefaniak, Purta, Bujnicki: "Human RNA cap1 methyltransferase CMTr1 cooperates with RNA helicase DHX15 to modify RNAs with highly structured 5' termini." in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 373, Issue 1762, (2018) (PubMed).
Aliases for CMTR1 抗体
cap methyltransferase 1 (CMTR1) 抗体 cap methyltransferase 1 (Cmtr1) 抗体 cap methyltransferase 1 (cmtr1) 抗体 cap methyltransferase 1 S homeolog (cmtr1.S) 抗体 1300018I05Rik 抗体 AI451264 抗体 FTSJD2 抗体 Ftsjd2 抗体 ftsjd2 抗体 hMTr1 抗体 KIAA0082 抗体 LRRG00129 抗体 mKIAA0082 抗体 MTr1 抗体 RGD1307801 抗体 zgc:55336 抗体