This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008].
Yoshida, Kim, Carver, Su, Weremowicz, Mulvey, Yamamoto, Brennan, Mei, Long, Yao, Polyak: "CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer." in: Cancer research, Vol. 75, Issue 7, pp. 1516-26, (2015) (PubMed).
Nam, Seo, Park, An, Kim, Yang, Kim, Jeong, Jin: "Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31157-63, (2010) (PubMed).
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
Aliases for CLK2 抗体
CDC like kinase 2 (CLK2) 抗体 CDC like kinase 2 S homeolog (clk2.S) 抗体 CDC like kinase 2 (clk2) 抗体 CDC-like kinase 2a (clk2a) 抗体 CDC like kinase 2 L homeolog (clk2.L) 抗体 CDC-like kinase 2 (Clk2) 抗体 AU041688 抗体 clk2 抗体 fb20c02 抗体 hclk2 抗体 hCLK2 抗体 MGC53993 抗体 MGC131228 抗体 si:ch211-81a5.7 抗体 Tu52 抗体 wu:fb20c02 抗体