This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010].
custom-made
CLDN2
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
CLDN2
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Randall, Henderson, Reens, Eckersley, Nyström, South, Balendran, Böttcher, Hughes, Price: "Claudin-2 Expression Levels in Ulcerative Colitis: Development and Validation of an In-Situ Hybridisation Assay for Therapeutic Studies." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162076, (2016) (PubMed).
Lim, Vedula, Hui, Kausalya, Hunziker, Lim: "Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopy." in: Experimental cell research, Vol. 314, Issue 14, pp. 2643-51, (2008) (PubMed).
Lim, Vedula, Hunziker, Lim: "Kinetics of adhesion mediated by extracellular loops of claudin-2 as revealed by single-molecule force spectroscopy." in: Journal of molecular biology, Vol. 381, Issue 3, pp. 681-91, (2008) (PubMed).