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抗Human IRF4 抗体:
抗Mouse (Murine) IRF4 抗体:
抗Rat (Rattus) IRF4 抗体:
Dog (Canine) Polyclonal IRF4 Primary Antibody for WB - ABIN2780429
Han, Kraft, Nan, Guo, Chen, Qureshi, Hankinson, Hu, Duffy, Zhao, Martin, Montgomery, Hayward, Thomas, Hoover, Chanock, Hunter: A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. in PLoS genetics 2008
Human Polyclonal IRF4 Primary Antibody for ELISA, ICC - ABIN4327575
Nagel, Pommerenke, Meyer, Kaufmann, MacLeod, Drexler: NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia. in Oncotarget 1970
In Pakistani population, the frequency of GCB (显示 GBA 抗体) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (显示 MME 抗体) and BCL6 (显示 BCL6 抗体) is 37.5%, and non- GCB (显示 GBA 抗体) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 is 62.5%.
Study confirmed a significant role for IRF4 rs12203592 and SLC45A2 (显示 SLC45A2 抗体) rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.
IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch (显示 NOTCH1 抗体) signaling pathway.
IRF4 signaling is essential for activin A (显示 INHBA 抗体) induced regulatory T cells that restrain asthmatic responses.
The data indicate that USP4 (显示 USP4 抗体) interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 (显示 IL4 抗体) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.
IRF4 is an independent prognostic factor for general MM patients.
Data show that the host transcript of miR (显示 MLXIP 抗体)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (显示 BCL11A 抗体).
Evidence for an essential role of Notch (显示 NOTCH1 抗体) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (显示 NOTCH1 抗体) signaling during CLL development.
These results show that significantly increased levels of FOXO3 (显示 FOXO3 抗体), IRF4, and xIAP (显示 XIAP 抗体) mRNA in Chinese HIV-1-infected patients.
Mechanistically, we found that BETi-mediated inhibition of cMYC (显示 MYC 抗体) correlates with the upregulation of miR (显示 MLXIP 抗体)-125b-5p and the downregulation of the cMYC (显示 MYC 抗体)/miR (显示 MLXIP 抗体)-125b-5p target gene IRF4, a transcriptional repressor of MICA (显示 MICA 抗体).
MBD2 (显示 MBD2 抗体) Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
study identifies IRF4 as central regulator of TH1 (显示 HAND1 抗体) responses and cellular metabolism. We propose that this function of IRF4 is fundamental for the initiation and maintenance of all TH cell responses.
Nur77 (显示 NR4A1 抗体) suppresses CD4 (显示 CD4 抗体)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (显示 GATA3 抗体)(+) and IL-4 (显示 IL4 抗体)(+) cells.
Muramyl dipeptide reduces fat inflammation and liver insulin (显示 INS 抗体) resistance via NOD2 (显示 NOD2 抗体). NOD1 (显示 NOD1 抗体)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (显示 INS 抗体)-sensitizing effects of NOD2 (显示 NOD2 抗体), but not NOD1 (显示 NOD1 抗体), muropeptides.
Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.
IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.
The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (显示 GATA3 抗体), SATB1 (显示 SATB1 抗体), and IRF4.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (显示 FOXO1 抗体), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
interferon regulatory factor 4
, Interferon regulatory factor 4
, lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, PWWP domain-containing protein MUM1
, mutated melanoma-associated antigen 1