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抗Human ABCA1 抗体:
抗Rat (Rattus) ABCA1 抗体:
抗Mouse (Murine) ABCA1 抗体:
Chicken Polyclonal ABCA1 Primary Antibody for ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. in Journal of lipid research 2004
Show all 259 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. in The Journal of biological chemistry 2002
Show all 13 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, IHC (fro) - ABIN268848
Murthy, Born, Mathur, Field: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. in Journal of lipid research 2002
Show all 13 Pubmed References
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. in PLoS ONE 2009
Show all 7 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3043773
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
Show all 5 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3044206
Chen: Effects of Chinese Herbal Compound "Xuemai Ning"on Rabbit Atherosclerosis Model and Expression of ABCA1. in International journal of biomedical science : IJBS 2013
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Human Monoclonal ABCA1 Primary Antibody for CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. in American journal of physiology. Renal physiology 2009
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Chicken Polyclonal ABCA1 Primary Antibody for ELISA, FACS - ABIN446266
Ingram, Crowther, Little, Freeman, Harliwong, Veleva, Hassall, Remke, Taylor, Hallahan: ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. in Experimental hematology & oncology 2013
Human Polyclonal ABCA1 Primary Antibody for IF (p), IHC (p) - ABIN732188
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for FACS, IF - ABIN2477218
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. in Pflügers Archiv : European journal of physiology 2007
This study provides evidence that, in HepG2 cells, GLP-1 (显示 GCG 抗体) may affect cholesterol homeostasis by regulating the expression of miR (显示 MLXIP 抗体)-758 and ABCA1.
Hsp27 (显示 HSPB1 抗体) may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K (显示 PIK3CA 抗体)/PKCzeta (显示 PRKCZ 抗体)/Sp1 (显示 PSG1 抗体) signal pathway in THP-1 (显示 GLI2 抗体) macrophage-derived foam cells
the present study revealed that overexpression of GLP1R (显示 GLP1R 抗体) significantly reduces proliferation, migration and cytokine release in ASM (显示 SMPD1 抗体) cells from COPD (显示 ARCN1 抗体) patients; this involved a significant increase in ABCA1 expression levels. This provided evidence to suggest that GLP1R (显示 GLP1R 抗体) may be a potential therapeutic target for the treatment of COPD (显示 ARCN1 抗体).
Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of spontaneous deliveries.
apoA-II (显示 APOA2 抗体) enhanced ABCA1-mediated cholesterol efflux
Cholesterol efflux from THP-1 (显示 GLI2 抗体) macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression.
identified HuR (显示 ELAVL1 抗体) as a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL (显示 HSD11B1 抗体) cholesterol levels.
Hepatic ABCA1 deficiency results in increased hepatic triglyceride and ANGPTL3 (显示 ANGPTL3 抗体) secretion, potentially underlying the elevated plasma triglyceride levels in Tangier disease patients.
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (显示 APOA1 抗体) and lipids metabolically segregate.
Hepatic free cholesterol content was significantly increased in NASH (显示 SAMSN1 抗体) as compared to non-NASH (显示 SAMSN1 抗体) subjects, while ABCA1 and ABCG1 (显示 ABCG1 抗体) protein levels significantly decreased with NASH (显示 SAMSN1 抗体) and fibrosis progression. The relative expression of miR (显示 MLXIP 抗体)-33a and miR (显示 MLXIP 抗体)-144 correlated inversely with ABCA1 but not with ABCG1 (显示 ABCG1 抗体) protein levels. miR (显示 MLXIP 抗体)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (显示 SAMSN1 抗体) in morbidly obese subjects.
our results highlight the importance of the LXR (显示 NR1H3 抗体)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (显示 SCARB1 抗体) or ABCG1 (显示 ABCG1 抗体) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (显示 HSD11B1 抗体) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
(1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin (显示 INS 抗体) signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin (显示 INS 抗体) resistance so that lipogenesis is suppressed but glucose metabolism remains normal
demonstrates behavior deficits caused by Abca1 deletion in APP (显示 APP 抗体)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (显示 APOE 抗体)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (显示 SCARB1 抗体) within RCT (显示 FOXE3 抗体).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (显示 CAV1 抗体) enhances internalization and degradation of ABCA1 by its association with ABCA1
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (显示 PCSK9 抗体) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (显示 APOA1 抗体)/ABCA1-mediated cholesterol efflux without STAT3 (显示 STAT3 抗体) activation can reduce proinflammatory cytokine expression in macrophages.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1