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Human FOXO3 ELISA Kit for Sandwich ELISA - ABIN1000112
Leti, Malenica, Doshi, Courtright, Van Keuren-Jensen, Legendre, Still, Gerhard, DiStefano: High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. in Translational research : the journal of laboratory and clinical medicine 2015
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Atorvastatin strengthens Skp2 binding to FOXO1 or ICAM1, leading to ubiquitination and degradation. Skp2-dependent ubiquitination of major pathogenic molecules is the key mechanism for statin's protective effect on endothelial function in diabetes.
Transcriptional factor PAX3 (PAX3 (显示 PAX3 ELISA试剂盒)) exerted its tumor suppressor function by inhibiting the activity of major signaling pathways and enhancing expression and activity of transcription factor forkhead box O3 protein (FOXO3a).
The result suggests that FOXO3 rs12212067 polymorphism does not play an important role in susceptibility to T. cruzi infection and/or chronic Chagas cardiomyopathy.
Overexpression of circ-Foxo3 decreased the interaction between Foxo3 and MDM2, and repressed the function of MDM2 in modulating poly-ubiquitination of Foxo3.
silencing FOXO3 diminishes bepridil- and trifluoperazine-induced apoptosis in triple-negative breast cancer cells
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (显示 PIK3CA ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) inhibitor causes loss of stemness and of FoxO1 (显示 FOXO1 ELISA试剂盒)/3 proteins in p53 (显示 TP53 ELISA试剂盒)-proficient glioblastoma multiforme stem cells (GBM-SCs (显示 TWIST1 ELISA试剂盒)).
The authors found that transient TUBB3 (显示 TUBB3 ELISA试剂盒) activation, through ABCB1 (显示 ABCB1 ELISA试剂盒), in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
findings provide further evidence for the involvement of FoxO3 during terminal erythropoiesis and confirm the modulation of the PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) pathway as a potential therapeutic strategy for beta-thalassemia
The data reveal a previously unexplored function of FOXO3a in gastric cancer invasion by regulating proteins involved in extracellular matrix degradation and Epithelial-Mesenchymal Transition. FOXO3a may be of prognostic value and a potential therapeutic target in blocking tumor metastasis.
pro-apoptotic role of miR (显示 MLXIP ELISA试剂盒)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
These results indicate that myostatin (显示 MSTN ELISA试剂盒) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (显示 NR3C1 ELISA试剂盒) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (显示 AKT1 ELISA试剂盒) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (显示 VHL ELISA试剂盒), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (显示 NR1H4 ELISA试剂盒) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
data show that the GSK3B (显示 GSK3b ELISA试剂盒)-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (显示 IGF1R ELISA试剂盒) after partial hepatectomy.
BIM-dependent death during CD8(+) T-cell deletion is FOXO3 independent.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 (显示 FBXO32 ELISA试剂盒) and its transcription factor FOXO3A.
MiR (显示 MLXIP ELISA试剂盒)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (显示 EOMES ELISA试剂盒) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (显示 HAND1 ELISA试剂盒) cell differentiation.
NO/protein kinase (显示 CDK7 ELISA试剂盒) G (PKG (显示 PRKG1 ELISA试剂盒))-dependent downregulation of PGC-1 alpha (显示 PPARGC1A ELISA试剂盒) and the ROS (显示 ROS1 ELISA试剂盒) detoxification system in endothelial cells are mediated by the PI3K/Akt (显示 AKT1 ELISA试剂盒) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (显示 ROS1 ELISA试剂盒)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like