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Nectin (显示 PVRL1 蛋白)-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (显示 AMICA1 蛋白) (JAM (显示 F11R 蛋白))-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 (显示 PVRL3 蛋白) and JAM (显示 F11R 蛋白)-based cell-cell adhesion sites to form AJ- and TJ-like domains.
NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation.
Findings clearly reveal the structural basis for the cis (显示 CISH 蛋白)-dimerization of nectins through the first Ig-like domains.
A link might exist between NECL1 and the extracellular matrix protein OPN (显示 SPP1 蛋白) in inhibiting the migration and invasion of U251 glioma ce
NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis.
Nec- 1 (显示 PCSK1 蛋白) suppress the growth and tumorigenic ability of colon cancer cells.
Necl-1 is a neural-tissue-specific Ca2 (显示 CA2 蛋白)+-independent immunoglobulin-like cell-cell adhesion molecule (显示 PCDHB16 蛋白) which potentially has membrane-associated guanylate kinase (显示 GUK1 蛋白) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
crystallographic analysis of human Nectin (显示 PVRL1 蛋白)-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule (显示 PCDHB16 蛋白)
human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS
Expression of entry receptors nectin-1 (显示 PVRL1 蛋白) and HVEM (显示 TNFRSF14 蛋白) prevent entry of HSV-1 into human conjunctival epithelium.
Our results suggest that Cadm3 may act as a negative regulator of peripheral nerve myelination, potentially through the selective regulation of the signaling cascades activated in Schwann cells by axonal contact, and in particular by type III Nrg-1 (显示 NRG1 蛋白).
Necl-1 is a neural-tissue-specific Ca2 (显示 CA2 蛋白)+-independent immunoglobulin-like cell-cell adhesion molecule (显示 PCDHb5 蛋白) which potentially has membrane-associated guanylate kinase (显示 GUK1 蛋白) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3\; MIM 607147) (Kakunaga et al., 2005
, TSLC1-like protein 1
, brain immunoglobulin receptor
, dendritic cell nectin-like protein 1 short isoform
, immunoglobulin superfamily member 4B
, immunoglobulin superfamily, member 4B
, nectin-like 1
, nectin-like protein 1
, synaptic cell adhesion molecule 3
, nectin-lke 1