This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Latest Publications for our Ceramide Synthase 2 抗体
Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: "Bcl2L13 is a ceramide synthase inhibitor in glioblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 15, pp. 5682-7, (2014) (PubMed).
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).
Laviad, Kelly, Merrill, Futerman: "Modulation of ceramide synthase activity via dimerization." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 21025-33, (2012) (PubMed).