The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].
Liao, Wu, Cheng, Li, Yi, Cao, Shuai: "Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome." in: BioMed research international, Vol. 2017, pp. 9429314, (2018) (PubMed).
Ozkorucu, Cetin, Sav, Yildiz: "Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome." in: International urology and nephrology, Vol. 48, Issue 7, pp. 1187-96, (2017) (PubMed).
Veinalde, Grossardt, Hartmann, Bourgeois-Daigneault, Bell, Jäger, von Kalle, Ungerechts, Engeland: "Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation." in: Oncoimmunology, Vol. 6, Issue 4, pp. e1285992, (2017) (PubMed).
Du, Dong, Zhao, Fu, Wang, Chen, Ou, Li, Sun, Tang, Song: "Immunostimulatory and anti-neoplasm effects of a novel palindrome CpG oligodeoxynucleotide in mice." in: Acta pharmacologica Sinica, Vol. 33, Issue 8, pp. 1047-54, (2012) (PubMed).