This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Lindblom, Aeinehband, Ström, Al Nimer, Sandholm, Khademi, Nilsson, Piehl, Ekdahl: "Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function." in: Clinical immunology (Orlando, Fla.), Vol. 166-167, pp. 89-95, (2016) (PubMed).
Lindblom, Berg, Ström, Aeinehband, Dominguez, Al Nimer, Abdelmagid, Heinig, Zelano, Harnesk, Hübner, Nilsson, Ekdahl, Diez, Cullheim, Piehl: "Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response." in: Journal of neuroinflammation, Vol. 12, pp. 192, (2015) (PubMed).