CCDC98 抗体
(Family with Sequence Similarity 175, Member A (FAM175A))
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of brca1 (By similarity).
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Latest Publications for our CCDC98 抗体
: "CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 710-5, (2007) (PubMed).: "CCDC98 targets BRCA1 to DNA damage sites." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 716-20, (2007) (PubMed).
: "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1194-8, (2007) (PubMed).
Aliases for CCDC98 抗体
abraxas 1, BRCA1 A complex subunit (ABRAXAS1) 抗体Coiled-coil domain-containing protein 98 (abraxas1) 抗体
BRCA1 A complex subunit (Abraxas1) 抗体
abraxas 1, BRCA1 A complex subunit (Abraxas1) 抗体
family with sequence similarity 175 member A (FAM175A) 抗体
abraxas 2a, BRISC complex subunit (abraxas2a) 抗体
abraxas 1, BRCA1 A complex subunit S homeolog (abraxas1.S) 抗体
3830405G04Rik 抗体
5630400M01Rik 抗体
abra1 抗体
ABRA1 抗体
AI506069 抗体
AL024423 抗体
AV118690 抗体
CCDC98 抗体
ccdc98 抗体
Ccdc98 抗体
fam175a 抗体
RGD1305287 抗体
zgc:103522 抗体
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