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CBX8 产品

(Chromobox Homolog 8 (CBX8))

Categories

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

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Featured CBX8 Categories

CBX8 抗体

High quality antibodies with extensive validation data.

CBX8 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBX8 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (1)
  • (4)
Cat. No. ABIN1724765
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (1)
  • (4)
Cat. No. ABIN1724766
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
Cat. No. ABIN7147709
Quantity 100 μL
Datasheet Datasheet

Recommended CBX8 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348218
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3090750
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3130472
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CBX8 Products

Lee, Um, Kim: "CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells." in: Biochemical and biophysical research communications, Vol. 469, Issue 4, pp. 884-90, (2016) (PubMed).

Maertens, El Messaoudi-Aubert, Elderkin, Hiom, Peters: "Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor." in: The EMBO journal, Vol. 29, Issue 15, pp. 2553-65, (2010) (PubMed).

Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus." in: The EMBO journal, Vol. 26, Issue 6, pp. 1637-48, (2007) (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Bárdos, Saurin, Tissot, Duprez, Freemont: "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28785-92, (2000) (PubMed).

Synonyms and alternative names related to CBX8

chromobox 8 (cbx8), chromobox 8 (CBX8), chromobox 8 (Cbx8), chromobox 8 S homeolog (cbx8.S), chromobox homolog 8a (Pc class homolog, Drosophila) (cbx8a), cbx8, MGC147589, Pc3, PC3, RC1

Protein level used designations for CBX8

  • chromobox homolog 8
  • chromobox protein homolog 8
  • mPc3
  • polycomb 3 homolog
  • Pc class 3 homolog
  • chromobox homolog 8 (Pc class homolog, Drosophila)
  • polycomb 3
  • rectachrome 1
  • chromobox-like protein 8
  • chromobox homolog 8 (Pc class homolog)
  • chromobox homolog 8a
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