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抗Human TJP1 抗体:
抗Mouse (Murine) TJP1 抗体:
抗Rat (Rattus) TJP1 抗体:
Human Polyclonal TJP1 Primary Antibody for IF (cc), IF (p) - ABIN675024
Gu, Xue, Wei, Zhang, Li: Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats. in Neuroscience letters 2011
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Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359733
Gangl, Reininger, Bernhard, Campana, Pree, Reisinger, Kneidinger, Kundi, Dolznig, Thurnher, Valent, Chen, Vrtala, Spitzauer, Valenta, Niederberger: Cigarette smoke facilitates allergen penetration across respiratory epithelium. in Allergy 2009
Show all 2 Pubmed References
Human Polyclonal TJP1 Primary Antibody for ELISA, WB - ABIN4359730
Zhong, Deane, Ali, Parisi, Shapovalov, OBanion, Stojanovic, Sagare, Boillee, Cleveland, Zlokovic: ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. in Nature neuroscience 2008
Human Polyclonal TJP1 Primary Antibody for IF - ABIN2192206
Balda, Anderson: Two classes of tight junctions are revealed by ZO-1 isoforms. in The American journal of physiology 1993
Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359735
McIntyre, Alev, Mechael, Salci, Lee, Fiebig-Comyn, Guezguez, Wu, Sheng, Bhatia: Expansive generation of functional airway epithelium from human embryonic stem cells. in Stem cells translational medicine 2014
The tight junction protein ZO-1 exists in stretched and folded conformations within epithelial cells, depending on actomyosin-generated force.
miR103 was upregulated in CRC (显示 CALR 抗体). Overexpression of miR103 promoted CRC (显示 CALR 抗体) cell proliferation and migration in vitro, whereas downregulation of miR103 inhibited cell proliferation and migration. ZO1 was identified as a direct target of miR103, revealing its expression to be inversely correlated with miR103 expression in CRC (显示 CALR 抗体) samples.
SHANK3 expression correl (显示 SHANK3 抗体)ated with ZO-1 and PKCepsilon in colonic tissue of (显示 SHANK3 抗体) patients with Crohn's disease. The expression level of SHANK3 affects ZO-1 expres (显示 SHANK3 抗体)sion and the barrier function in intestina (显示 PRKCE 抗体)l epithelial cells.
These results indicate the varying effects of 7-oxygenated cholesterol molecules on the expression and localization of ZO-1 depending on cell types, and suggest the contribution of 7-oxygeneted cholesterol molecules to the structural alteration of tight junctions.
CTR (显示 CALCR 抗体) activates AKAP2 (显示 AKAP2 抗体)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3 (显示 CLDN3 抗体).
the Ras signaling pathway is involved in HIV-1 Tat (显示 TAT 抗体)-induced changes in ZO-1 and NEP (显示 MME 抗体).
decreased interaction between ZO-1 and occludin (显示 OCLN 抗体) might contribute to the epiphora occurred in the transplanted submandibular glands
integration of claudin-2 (显示 CLDN2 抗体), occludin (显示 OCLN 抗体) and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.
Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin (显示 OCLN 抗体) and zonula occludens 1.
The role of estrogens in the regulation of ZO-1 and estrogen receptors 1 and 2 was evaluated in human primary gut (显示 GUSB 抗体) tissues by immunohistochemistry, immunofluorescence and qPCR.
Busulfan treatment down-regulated the epididymal expression of vimentin (显示 VIM 抗体) and zonula occludens-1 (ZO-1).
At 3days after the first tamoxifen injection, Akt1 (显示 AKT1 抗体)(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43 (显示 GJA1 抗体)) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1 (显示 AKT1 抗体)/2 silencing significantly decreased both Cx43 (显示 GJA1 抗体) and ZO-1 expression
Overexpression of SHANK3 (显示 SHANK3 抗体) enhanced ZO-1 expression, and knockdown of SHANK3 (显示 SHANK3 抗体) resulted in decreased expression of ZO-1. Regulation of ZO-1 expression by SHANK3 (显示 SHANK3 抗体) seems to be mediated through a PKCepsilon (显示 PRKCE 抗体)-dependent pathway. The expression level of SHANK3 (显示 SHANK3 抗体) affects ZO-1 expression and the barrier function in intestinal epithelial cells in mice.
STAT3 (显示 STAT3 抗体) activation downregulates the ZO-1 and occludin (显示 OCLN 抗体) levels and increases the endothelial permeability through the induction of VEGF (显示 VEGFA 抗体) production in retinal endothelial cells.
Cx43 (显示 GJA1 抗体) tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells.
Expression of Podocalyxin (显示 PODXL 抗体), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 (显示 TJP2 抗体) and this correlates with an aberrant submembranous localization of Ezrin (显示 EZR 抗体).
Zonula occludens-1, occludin (显示 OCLN 抗体) and E-cadherin (显示 CDH1 抗体) expression and organization in salivary glands
Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target.
Arecoline increases the production of TNF-alpha (显示 TNF 抗体) and induces protein redistribution of ZO-1.
cyclic strain modulates both the expression and phosphorylation state of occludin (显示 OCLN 抗体) and ZO-1 in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
ZO-1 and occludin (显示 OCLN 抗体) are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin (显示 OCLN 抗体) at the blastocyst stage.
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.
tight junction protein ZO-1
, zona occludens 1
, zona occludens protein 1
, zonula occludens 1 protein
, zonula occludens protein 1
, tight junction protein 1 (zona occludens 1)
, zonula occludens 1