Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
Tanaka, Ishii, Kasai, Yoon, Saeki: "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10506-15, (2007) (PubMed).
Ledent, Demeestere, Blum, Petermans, Hämäläinen, Smits, Vassart: "Premature ovarian aging in mice deficient for Gpr3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 25, pp. 8922-6, (2005) (PubMed).