Use your antibodies-online credentials, if available.
Select your species
Through experiments with chimeras of MCP-1 and MCP-3, we identified the chemokine amino-terminal region as being the primary determinant of both the binding and signaling selectivity of these two chemokines at CCR2.
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate Gene for Celiac Disease Pathogenesis
Studies indicate manipulating CCL2-CCR2 interaction as a potential approach for combating metastatic disease.
Interruption of either CCL2 (显示 CCL2 ELISA试剂盒)-CCR2 signaling or cathepsin B (显示 CTSB ELISA试剂盒) function significantly impaired perineural invasion (PNI (显示 SERPINE2 ELISA试剂盒)).
No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism with colorectal cancer prevalence
CCR2 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits.
These data suggest that CCR1/CCR2B could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.
systemic mRNA expression of CCR2 strongly differentiated children who failed to achieve asthma control with triamcinolone administration
Basophil migration into skin lesions of Systemic Lupus Erythematosus patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils.
The CCR2 (+190 G/A) GG genotype frequencies for patients were significantly higher in the stage III-IV cancer group ( p = 0.036), and A allele carriers were significantly higher in the stage I-II ovarian cancer group.
Chemokine receptor 2 (CCR2(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (显示 CD3E ELISA试剂盒)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (显示 CCL1 ELISA试剂盒) CCL2 (显示 CCL2 ELISA试剂盒), a ligand for CCR2, included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta (显示 IL1B ELISA试剂盒) was greater in FACS-isolated microglia than in brain-invading monocytes
TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice.
Suggest role for CCR2 expression in podocytes to mediate diabetic renal injury, independent of monocyte/macrophage recruitment.
CCL2 recruits T cells into the brain in a CCR2-independent manner.
in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T cell cytokines, and its absence on T cells results in attenuated colitis progression
tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment
CCR2 expression on bone marrow-derived cells, likely macrophages, is essential to muscle regeneration independent of TLR signaling, aging, and sex.
we demonstrated that CX3CR1 (显示 CX3CR1 ELISA试剂盒)(Lo)CCR2(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1 (显示 CX3CR1 ELISA试剂盒)(Hi)CCR2(Lo) macrophages and CX3CR1 (显示 CX3CR1 ELISA试剂盒)(Hi)CCR2(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (显示 CCNA1 ELISA试剂盒) population, with resident microglia accounting for the approximately 15% remaining.
we characterized a novel regulatory network in macrophages, in which CCR2 activates PI3K-AKT (显示 AKT1 ELISA试剂盒)-mTOR (显示 FRAP1 ELISA试剂盒) signaling to mediate HIF-1alpha (显示 HIF1A ELISA试剂盒) expression, which then drives VEGF-C (显示 VEGFC ELISA试剂盒) expression to promote lymphangiogenesis.
CXCR4 (显示 CXCR4 ELISA试剂盒), CCR2, and CX3CR1 (显示 CX3CR1 ELISA试剂盒) direct dendritic cell precursors from the bone marrow to the lung differentially.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor