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Human Monoclonal CAP1 Primary Antibody for ELISA, WB - ABIN564567
Cauwe, Martens, Van den Steen, Proost, Van Aelst, Blockmans, Opdenakker: Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9. in Experimental cell research 2008
Show all 2 Pubmed References
Human Polyclonal CAP1 Primary Antibody for IF, IP - ABIN950065
Jansen, Collins, Golden, Sokolova, Goode: Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. in The Journal of biological chemistry 2014
Human Polyclonal CAP1 Primary Antibody for FACS, IF - ABIN523895
Wakeel, Kuriakose, McBride: An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. in Infection and immunity 2009
RETN and CAP1 polymorphisms and gene expression may be potential biomarkers for breast cancer risk
Significant up-regulation of PBMCs CAP1, CD36 mRNA and plasma resistin found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin could be able to exert its effects stronger on cells with up-regulated CAP1 mRNA thus contributing atherosclerosis development.
REVIEW: summarizes information available to date about the structural organization, regulation of functional activity of adenylyl cyclase-associated protein 1 (CAP1), and its participation in cellular processes
Results identify a role for CAP1 in regulating proliferative transformation of cancer cells, with ERK signaling playing pivotal roles in mediating both cell functions.
CAP1 expression is markedly increased in human glioma and that downregulation of CAP1 in tumors may serve as a treatment for glioma patients.
our results indicated that CAP1 participated in the molecular pathological process of glioma
a high expression of CAP1 is involved in the pathogenesis of EOC, and that the downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC.
This study demonstrated an inverse relationship between CAP1 and MMP-9 expression, high expression of MMP-9 and low expression of CAP1 in those with chronic obstructive pulmonary disease compared with the non-chronic obstructive pulmonary disease group.
CAP1 is involved in the brain metastasis in non-small cell lung cancer.CAP1 overexpression is associated with poor prognosis in non-small cell lung cancer patients.
Overexpression of CAP1 in monocytes enhanced the resistin-induced increased activity of the cAMP-dependent signaling.
results indicate that upregulated expression of CAP1 might contribute heavily to the metastasis of hepatocellular carcinoma.
Overexpression of CAP1 is associated with breast carcinoma.
CAP1 might be a potential molecular targeted therapy for surgery and immune treatment.
overexpression of CAP1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer.
CAP1 depletion also led to changes in cofilin phosphorylation and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading.
Findings suggest that CAP1 (cyclase-associated protein 1) is involved in the metastasis of esophageal squamous cell carcinoma, and increased expression may indicate a poor prognosis.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament
Based on an analysis of 1075 beta-thalassemia alleles the CAP+1 (A-->C) mutation constituted 3.2% of north Indians.
The high turnover rate of CAP1 by MMP-9, comparable to that of gelatin as the natural extracellular substrate of this enzyme, may be critical to prevent pathological conditions associated with considerable cytolysis.
The structural basis of actin monomer re-charging by CAP1 protein has been reported.
Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton.
a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
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study provides evidence that catalyzing nucleotide exchange on actin monomers via the beta-sheet domain is the most highly conserved function of CAPs from mammals to apicomplexan parasites.
CAP1 is widely expressed in mouse nonmuscle cells and promotes cofilin-induced actin dynamics.
CAP1 shows a broad tissue distribution and localizes to the cytoplasm
Postsynaptic adenylyl cyclase 1 is required for functional maturation of thalamocortical synapses and morphological barrels.
These studies suggest that CAP1 provides a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle.
cap1 regulates cortical actin distribution specifically in the anterior mesendoderm of the zebrafish gastrula.
The requirement of Cap1 for a cellular apical constriction step suggests a conservation of gene function for a cell biological event critical to many developmental processes.
Bovine herpesvirus 1 infection stimulates caspase 1 activity.
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified.
, adenylyl cyclase-associated protein 1
, CAP, adenylate cyclase-associated protein 1 (yeast)
, adenylyl cyclase-associated protein
, CAP, adenylate cyclase-associated protein 1
, Adenylyl cyclase-associated protein 1
, adenylyl cyclase-associated CAP protein homolog 1 iae
, adenylyl cyclase-associated CAP protein, yeast homolog 1
, cyclase-associated protein homologue
, ASP-56 protein
, TNF receptor-associated factor 3
, adenylate cyclase associated protein 1