抗Mouse (Murine) beta 2 Adrenergic Receptor 抗体:
抗Human beta 2 Adrenergic Receptor 抗体:
抗Rat (Rattus) beta 2 Adrenergic Receptor 抗体:
Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for ELISA, WB - ABIN543800
Cherezov, Rosenbaum, Hanson, Rasmussen, Thian, Kobilka, Choi, Kuhn, Weis, Kobilka, Stevens: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. in Science (New York, N.Y.) 2007
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Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for FACS, WB - ABIN513155
Lencesova, Sirova, Csaderova, Laukova, Sulova, Kvetnansky, Krizanova: Changes and role of adrenoceptors in PC12 cells after phenylephrine administration and apoptosis induction. in Neurochemistry international 2010
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Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for DB, ELISA - ABIN548694
Wolfarth, Rankinen, Mühlbauer, Scherr, Boulay, Pérusse, Rauramaa, Bouchard: Association between a beta2-adrenergic receptor polymorphism and elite endurance performance. in Metabolism: clinical and experimental 2007
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Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for FACS, IF (p) - ABIN730153
Fan, Liao, Tang, Chen, Zhang, Liu, Zhong: Role of ?2-adrenoceptor-?-arrestin2-nuclear factor-?B signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis. in Chinese journal of integrative medicine 2012
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Human Monoclonal beta 2 Adrenergic Receptor Primary Antibody for Func, IA - ABIN2192080
Lebesgue, Wallukat, Mijares, Granier, Argibay, Hoebeke: An agonist-like monoclonal antibody against the human beta2-adrenoceptor. in European journal of pharmacology 1998
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Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for ELISA, WB - ABIN547523
Elefteriou, Ahn, Takeda, Starbuck, Yang, Liu, Kondo, Richards, Bannon, Noda, Clement, Vaisse, Karsenty: Leptin regulation of bone resorption by the sympathetic nervous system and CART. in Nature 2005
Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for IHC, IHC (p) - ABIN4284397
Ciurea, Rogoveanu, Pirici, Târtea, Streba, Florescu, Cătălin, Puiu, Târtea, Vere: B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma. in World journal of gastroenterology 2017
Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for IF, IHC (p) - ABIN498188
Müller, Schwab, Rosenfeld, Antonow-Schlorke, Nathanielsz, Rakers, Schubert, Witte, Rupprecht: Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation. in Journal of vascular research 2017
Human Polyclonal beta 2 Adrenergic Receptor Primary Antibody for ELISA, WB - ABIN185478
Rekawiecki, Nowocin, Kotwica: Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow. in Prostaglandins & other lipid mediators 2010
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Zebrafish larvae lacking beta1AR expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
Genetic deletion of adrenergic receptor beta 2 exacerbates high-fat diet -induced hepatic lipid accumulation and liver injury.
Findings reveal a critical role for ADRB2 signaling in controlling inflammation through the rapid induction of IL-10. Findings provide a fundamental insight into how the sympathetic nervous system controls a critical facet of immune function through ADRB2 signaling.
Thus, leptin increases glucose uptake and enhances insulin signalling in red-type skeletal muscle via activation of sympathetic nerves and beta2-adrenergic receptor in muscle and in a manner independent of muscle AMP-activated protein kinase.
Studies suggest role for beta-2 adrenoceptor (beta2-AR) in regulating cAMP intracellular levels that can modify suppressive function in T regulatory (TREG) cells.
these findings demonstrate an important role for host beta2AR signaling in suppressing T cell reconstitution and graft-versus-tumor activity.
Mechanistically, Adrb2 loss increases production of Vascular Endothelial Growth Factor-A (VEGF-A) in female neonatal beta-cells and results in hyper-vascularized islets during development, which in turn, disrupts insulin production and exocytosis.
betaeta 2-adrenergic receptor (beta2-AR) signaling can inhibit CD8(+) T-cell activation is by suppressing the required metabolic reprogramming events.
we identified the beta2 adrenergic receptor (ADRB2) as a downstream target for PHD3 in skeletal muscle
Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts.
Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility.
this review discusses beta2-adrenoceptor function in asthma
the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Cav1.2 and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.
activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP at Thr668
Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes
beta2-AR deletion is associated to selective hepatic insulin resistance and preserved skeletal muscle insulin sensitivity.
The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.
knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 upon beta-adrenergic stimulation rendering Cav1.2 refractory for several minutes from further beta-adrenergic stimulation.
The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism.
ADRb2 shows lipid scrambling activity.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)
beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance
Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by beta-2 Adrenoceptors in Human Airway Smooth-Muscle Cells
Expression of the C79G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs. CC: OR, 0.69; 95% CI, 0.55-0.88) and the recessive model (GG vs. CC+CG: OR, 0.65; 95% CI, 0.53-0.81). The C79G polymorphism was associated with a reduced risk for the development of pediatric asthma.
no significant association between haplotypes of both single nucleotide polymorphisms (arg16gly and gln27glu) and asthma (p>0.05); adrenergic receptor b2 did not contribute markedly to susceptibility to asthma (p>0.05) (Meta-Analysis)
ADRB2 is negatively regulated by miR-15a-5p, which inhibits IL-13-induced nasal epithelial inflammatory responses.
Data show that an alanine mutant residue tyrosine 219 (Y219A) in transmembrane domain five of the beta2-adrenergic receptor (beta2AR) was incapable of beta-arrestin recruitment or receptor internalization.
Results have been able to identify how different phospholipids differentially modulate beta2AR activity as : partial inactivation, full deactivation or stable activation, and is seemingly governed by the chemistry of protein-interacting lipid headgroups.
Role of beta2-adrenergic receptor gene polymorphism (rs2400707) in fear and ecxtinction memory.
Authors conclude that the preferential mobilization of NK-cells, non-classical monocytes and differentiated subsets of CD8+ T-cells with exercise is largely dependent on catecholamine signaling through the beta2-AR.
this study shows that abnormal beta2-adrenoceptor phosphorylation in airway smooth muscle cells is present constitutively in cells from severe asthmatics
the data obtained in this study suggest that EHD1 plays a critical role in Non-small cell lung cancer (NSCLC) angiogenesis via b2AR signaling and highlight a potential target for antiangiogenic therapy.
findings suggest that the MBL2 and ADRB2 genes exert an important genetic influence on cystic fibrosis lung disease
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the beta2-AR gene are associated with asthma severity and response to therapy.
preliminary evidence that beta2 -AR Arg16Gly genotype has a significant effect on fat-free mass, muscle strength and motor unit behaviour in humans.
PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma.
Polymorphism Gln27Glu of beta2 adrenergic receptors is associated with lower myocardial infarction rate.
adrenergic receptor polymorphism at codon 27 is not associated with asthma susceptibility in Egyptian children
The presence of the G allele and genotype G/G Gln27Glu of the ADRB2 gene are at risk for development and progression of obesity in patients with coronary heart disease.
Polymorphisms within ADRB2 as associated with increased risk of bronchial asthma in children and adolescents.
Arg16Gly polymorphism not associated with pulmonary response to asthma treatment with inhaled corticosteroids plus long-acting beta2-agonists [review]
We found that coronary artery disease patients harboring the ADRB2 rs1042714 Glu27 allele exhibited a positive association with cardiovascular events (risk ratio [RR] = 1.31, 95% confidence interval [CI]: 1.08-1.58, p = 0.006), but not with all-cause mortality (RR = 0.97, 95% CI: 0.70-1.35, p = 0.859).
A persistent B2R-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA.
These data collectively reveal the potential of beta2ARag to improve skin scarring.
Beta(1)- and beta(2)-adrenoceptors contribute to the beta-feedforward coronary resistance vessel dilation during exercise.
Prolactin infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway
Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release.
The results imply ADRB-2-mediated actions in the development of primate follicles
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
adrenergic receptor beta-2
, adrenergic, beta-2-, receptor, surface
, beta-2 adrenergic receptor
, beta-2b-adrenergic receptor
, beta-2 adrenoceptor
, beta-2 adrenoreceptor
, beta 2-AR
, adrenergic receptor beta 2
, adrenergic, beta-2, receptor, surface
, catecholamine receptor
, beta2-adrenergic receptor
, Adrenergic beta 2- receptor surface
, adrenergic receptor, beta 2
, Beta-2 adrenergic receptor
, Beta-2 adrenoceptor
, Beta-2 adrenoreceptor
, beta 2 adrenergic receptor
, beta-2-adrenergic receptor