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抗Mouse (Murine) 抗体:
Cow (Bovine) Polyclonal ADCY10 Primary Antibody for WB - ABIN2782970
Schmid, Sutto, Nlend, Horvath, Schmid, Buck, Levin, Conner, Fregien, Salathe: Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. in The Journal of general physiology 2007
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results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition.
The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption.
Evaluation of soluble adenylyl cyclase expression using R21 antibody is a useful diagnostic adjunct in the evaluation of margins of LM during slow Mohs surgery.
shows that in fibroblast cultures inhibition by KH7 of production in the mitochondrial matrix by soluble adenylyl cyclase
Crystal structures of human ADCY10 catalytic domains in complex with nucleotides.
Soluble adenylyl cyclase plays a role in the regulation of basal cCMP and cUMP.
sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness.
sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo.
a haem-binding domain within the C-terminus of the human soluble adenylate cyclase
Significant overexpression of soluble type 10 adenylyl cyclase (sAC), an alternative source of cAMP, was found in human prostate carcinoma.
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression
Soluble adenylyl cyclase is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency.
These results show that bicarbonate-controlled sAC stimulation must be taken into account in cell physiology and that basal CFTR expression depends on an ionic parameter.
a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women.
This study showed that sAC is essential for lysosomal acidification in addition to its other roles in cell physiology.
cAMP pathways are compartmentalized in sperm, with Gs proteins and transmembrane adenyl cyclase in the head and Adcy10 and PKA in the flagellum.
Soluble guanylyl cyclase expression is reduced in experimental asthma contributing to the observed airway hyperreactivity.
The role of nitric oxide synthase 3 in the activation of soluble guanylyl cyclase in platelets is reported.
Plays a critical role in cAMP signaling in spermatozoa; defective cAMP production prevents engagement of multiple components of capacitation resulting in male infertility.
sperm-specific Na+/H+ exchanger is required for the expression of full-length soluble adenylyl cyclase
These results suggest that NO regulation of MMP-9 secreted from macrophages may occur chemically by reactive nitrogen species-mediated protein modification, biologically through soluble guanylyl-cyclase.
External Ca2+ binds an unidentified extracellular protein that is required for HCO3(-) to engage cyclic AMP-mediated activation of motility.
Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation.
functional ADCY10 ortholog proteins exist in the heads of boar spermatozoa.
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3',5'-cyclic AMP synthetase
, AH-related protein
, ATP pyrophosphate-lyase
, adenylate cyclase type 10
, germ cell soluble adenylyl cyclase
, testicular soluble adenylyl cyclase (SAC)
, soluble adenylyl cyclase
, testicular soluble adenylyl cyclase
, adenylate cyclase 10 (soluble)
, adenylate cyclase type 10 variant I (full-length form)
, adenylate cyclase type 10 variant II (truncated form)
, LOW QUALITY PROTEIN: adenylate cyclase type 10
, adenylate cyclase 10, soluble