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C1q 产品

(Complement Fragment C1q (C1q))
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

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Featured C1q Categories

C1q 抗体

High quality antibodies with extensive validation data.

C1q ELISA试剂盒

Reliable ELISA kits for a wide range of species.

C1q 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended C1q 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC (fro)
Validations
  • (3)
Cat. No. ABIN2477784
Quantity 1 mL
Datasheet Datasheet
Reactivity Mouse
Application FACS, IHC (fro), IF, Func
Validations
  • (3)
Cat. No. ABIN2191846
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Application FACS, IA
Validations
  • (5)
Cat. No. ABIN2191787
Quantity 100 μg
Datasheet Datasheet

Recommended C1q ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6955043
Quantity 96 tests
Datasheet Datasheet
Reactivity Monkey
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6963095
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6999543
Quantity 96 tests
Datasheet Datasheet

Recommended C1q 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN1062256
Quantity 200 μg
Datasheet Datasheet

Latest Publications for our C1q Products

Silva-Cardoso, Tao, Fernández, Boes, Radstake, Pandit: "CXCL4 suppresses tolerogenic immune signature of monocyte-derived dendritic cells." in: European journal of immunology, Vol. 50, Issue 10, pp. 1598-1601, (2021) (PubMed).

Huang, Cui, Gu, Zhang, Qu, Wang, Wang, Cheng, Meng, Liu, Zhao: "Complement activation profile of patients with primary focal segmental glomerulosclerosis." in: PLoS ONE, Vol. 15, Issue 6, pp. e0234934, (2020) (PubMed).

Sikora, Wróblewska-Czech, Smycz-Kubańska, Mielczarek-Palacz, Cygal, Witek, Kondera-Anasz: "The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis." in: Archives of gynecology and obstetrics, Vol. 297, Issue 6, pp. 1495-1501, (2018) (PubMed).

Eriksson, Studahl, Bergström: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." in: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).

Ma, Cui, Liao, Zhao: "Complement activation contributes to the injury and outcome of kidney in human anti-glomerular basement membrane disease." in: Journal of clinical immunology, Vol. 33, Issue 1, pp. 172-8, (2013) (PubMed).

Neiman, Fredolini, Johansson, Lehtiö, Nygren, Uhlén, Nilsson, Schwenk: "Selectivity analysis of single binder assays used in plasma protein profiling." in: Proteomics, Vol. 13, Issue 23-24, pp. 3406-10, (2013) (PubMed).

Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).

Erlich, Dumestre-Pérard, Ling, Lemaire-Vieille, Schoehn, Arlaud, Thielens, Gagnon, Cesbron: "Complement protein C1q forms a complex with cytotoxic prion protein oligomers." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19267-76, (2010) (PubMed).

Castellano, Melchiorre, Loverre, Ditonno, Montinaro, Rossini, Divella, Battaglia, Lucarelli, Annunziata, Palazzo, Selvaggi, Staffieri, Crovace, Daha, Mannesse, van Wetering, Paolo Schena, Grandaliano: "Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1648-59, (2010) (PubMed).

Ankeny, Guan, Popovich: "B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2990-9, (2009) (PubMed).

Synonyms and alternative names related to C1q

complement component 1, q subcomponent, alpha polypeptide (C1qa), AI255395, C1q

Protein level used designations for C1q

  • complement C1q subcomponent subunit A
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