Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011].
Wen, Zhou, Liu, Wang, Zhang, Liang: "Effect of the knockdown of Cabin1 on p53 in glomerular podocyte." in: Journal of receptor and signal transduction research, Vol. 36, Issue 2, pp. 173-80, (2016) (PubMed).
Aliases for CABIN1 抗体
calcineurin binding protein 1 (CABIN1) 抗体 calcineurin binding protein 1 (cabin1) 抗体 calcineurin binding protein 1 (Cabin1) 抗体 A330070M20Rik 抗体 CABIN1 抗体 CAIN 抗体 Cain 抗体 PPP3IN 抗体 Ppp3in 抗体