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人 BD Fc Block™

FACS 1 mg/mL
产品编号 ABIN2690968
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for 人 BD Fc Block™ (ABIN2690968)

应用范围

Flow Cytometry (FACS)
  • 适用

    人, 猕猴

    产品特性

    Fcγ Receptors belong to the immunoglobulin superfamily and are expressed at varying levels in multiple cell lineages including high expression in myeloid and B cells. The major functions of Fc receptors are protective functions of the immune system. There are multiple different types of Fc receptors reflecting a variety of different biological activities, which are modulated when they are aggregated by multivalent antigen-antibody complexes. While normally serving important physiological roles in the immune system, Fc Receptors can also be the cause of nonspecific, false-positive antibody staining of cells. Human BD Fc Block™ is designed and formulated to block or significantly reduce potential non-specific antibody staining caused by receptors for IgG that may be encountered in various applications including the flow cytometric analysis of human cells. Moreover, it can increase the specificity of antibody labeling of extremely rare target cells such as antigen-specific B cells, fetal cells in maternal blood, hematopoietic progenitor cells, or disseminated epithelial tumor cells.

    过滤

    Sterile filtered,0.2 μm filtered

    内毒素水平

    Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    BD Pharmingen™ Human BD Fc Block™ - Purified NA/LE Reactivity Hu, Rhe

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

    储存液

    Azide free

    储存条件

    4 °C

    储存方法

    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Nimmerjahn, Ravetch: "Fc-receptors as regulators of immunity." in: Advances in immunology, Vol. 96, pp. 179-204, (2007) (PubMed).

    Ravetch, Bolland: "IgG Fc receptors." in: Annual review of immunology, Vol. 19, pp. 275-90, (2001) (PubMed).

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