BTBD12 抗体
(BTB (POZ) Domain Containing 12 (BTBD12))
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].
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Latest Publications for our BTBD12 抗体
: "Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation." in: Cell biochemistry and biophysics, (2017) (PubMed).: "Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment." in: mBio, Vol. 7, Issue 5, (2016) (PubMed).
: "SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres." in: Cell reports, Vol. 4, Issue 5, pp. 861-9, (2013) (PubMed).
: "The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4." in: Human molecular genetics, Vol. 21, Issue 22, pp. 4948-56, (2012) (PubMed).
: "Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002094, (2011) (PubMed).
: "Mutations of the SLX4 gene in Fanconi anemia." in: Nature genetics, Vol. 43, Issue 2, pp. 142-6, (2011) (PubMed).
Aliases for BTBD12 抗体
SLX4 structure-specific endonuclease subunit (Slx4) 抗体SLX4 structure-specific endonuclease subunit (SLX4) 抗体
SLX4 structure-specific endonuclease subunit homolog (SLX4) 抗体
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4) 抗体
AI256635 抗体
AI426760 抗体
Btbd12 抗体
BTBD12 抗体
D16Bwg1016e 抗体
FANCP 抗体
MUS312 抗体
RGD1566009 抗体
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