BRCC3 抗体
(BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].
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Latest Publications for our BRCC3 抗体
: "SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy." in: PLoS pathogens, Vol. 14, Issue 5, pp. e1007071, (2018) (PubMed).: "BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation." in: Cancer research, Vol. 66, Issue 10, pp. 5039-46, (2006) (PubMed).
: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
Aliases for BRCC3 抗体
BRCA1/BRCA2-containing complex subunit 3 (BRCC3) 抗体DEP domain containing 1B (depdc1b) 抗体
BRCA1/BRCA2-containing complex subunit 3 (brcc3) 抗体
BRCA1/BRCA2-containing complex, subunit 3 (Brcc3) 抗体
BRCA1/BRCA2-containing complex subunit 3 L homeolog (brcc3.L) 抗体
BRCC3 抗体
brcc3 抗体
BRCC36 抗体
brcc36 抗体
C6.1A 抗体
CXorf53 抗体
xtp1 抗体
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