The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008].
Crews, Adame, Patrick, Delaney, Pham, Rockenstein, Hansen, Masliah: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, (2010) (PubMed).
Jukes, Both, Leusink, Sterk, van Blitterswijk, de Boer: "Endochondral bone tissue engineering using embryonic stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6840-5, (2008) (PubMed).
Aliases for BMP6 蛋白
bone morphogenetic protein 6 (BMP6) 蛋白 bone morphogenetic protein 6 (bmp6) 蛋白 bone morphogenetic protein 6 S homeolog (bmp6.S) 蛋白 bone morphogenetic protein 6 (Bmp6) 蛋白 BMP6 蛋白 D13Wsu115e 蛋白 vgr 蛋白 VGR 蛋白 vgr-1 蛋白 vgr1 蛋白 VGR1 蛋白 Vgr1 蛋白 zgc:113595 蛋白