Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Buhrke, Lengler, Lampen: "Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2." in: Development, growth & differentiation, Vol. 53, Issue 3, pp. 411-26, (2011) (PubMed).
Guo, Lukacik, Papagrigoriou, Meier, Lee, Adamski, Oppermann: "Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase." in: The Journal of biological chemistry, Vol. 281, Issue 15, pp. 10291-7, (2006) (PubMed).