ATP7B 产品
(ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))
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This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008].
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Featured ATP7B Categories
ATP7B 抗体
High quality antibodies with extensive validation data.
ATP7B ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ATP7B 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATP7B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7441340
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), FACS
Validations
- (7)
Cat. No.
ABIN390398
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN560009
Quantity
100 μg
Datasheet
Datasheet
Recommended ATP7B ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953997
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953998
Quantity
96 tests
Datasheet
Datasheet
Recommended ATP7B 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346157
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3113480
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3135599
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ATP7B Products
: "PAMAM dendrimer grafted cellulose paper scaffolds as a novel in vitro 3D liver model for drug screening applications." in: Colloids and surfaces. B, Biointerfaces, Vol. 172, pp. 346-354, (2019) (PubMed).: "The release and detection of copper ions from ultrasmall theranostic Cu2-xSe nanoparticles." in: Nanoscale, Vol. 11, Issue 24, pp. 11819-11829, (2019) (PubMed).
: "Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma." in: Frontiers in oncology, Vol. 9, pp. 958, (2019) (PubMed).
: "The loss of copper is associated with the increase in copper metabolism MURR domain 1 in ischemic hearts of mice." in: Experimental biology and medicine (Maywood, N.J.), Vol. 243, Issue 9, pp. 780-785, (2018) (PubMed).
: "A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals." in: Journal of the American Chemical Society, (2018) (PubMed).
: "miR-133a enhances the sensitivity of Hep-2 cells and vincristine-resistant Hep-2v cells to cisplatin by downregulating ATP7B expression." in: International journal of molecular medicine, Vol. 37, Issue 6, pp. 1636-42, (2016) (PubMed).
: "A Chinese herbal Formula, Chang-Wei-Qin, Synergistically Enhances Antitumor Effect of Oxaliplatin." in: Pathology oncology research : POR, Vol. 21, Issue 2, pp. 389-97, (2015) (PubMed).
: "Mechanistic basis of a combination D-penicillamine and platinum drugs synergistically inhibits tumor growth in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo." in: Biochemical pharmacology, Vol. 95, Issue 1, pp. 28-37, (2015) (PubMed).
: "Novel ATPase Cu(2+) transporting beta polypeptide mutations in Chinese families with Wilson's disease." in: PLoS ONE, Vol. 8, Issue 7, pp. e66526, (2013) (PubMed).
: "Is ATP7B a predictive marker in patients with ovarian carcinoma treated with platinum-taxane combination chemotherapy?" in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 23, Issue 1, pp. 60-4, (2012) (PubMed).
Synonyms and alternative names related to ATP7B
ATPase copper transporting beta (ATP7B), ATPase, Cu++ transporting, beta polypeptide (Atp7b), ATPase copper transporting beta (Atp7b), ATPase, Cu++ transporting, beta polypeptide (Wilson disease) (atp7b), copper-transporting ATPase 2 (LOC592143), ATPase, Cu++ transporting, beta polypeptide (atp7b), ATPase copper transporting beta (atp7b), Atp7a, ATP7B, Hts, PINA, PWD, tx, WC1, WD, Wd, WNDProtein level used designations for ATP7B
- ATPase, Cu(2+)- transporting, beta polypeptide
- Wilson disease-associated protein
- copper pump 2
- copper-transporting ATPase 2
- Wilson protein
- toxic milk
- wilson disease-associated protein homolog
- ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)
- PINA gene, promoter
- pineal night-specific ATPase
- ATPase 7B protein
- ATPase, Cu++ transporting, beta polypeptide (Wilson disease)
- Wilson's disease protein
- copper-transporting ATPase
- ATPase, Cu++ transporting, beta polypeptide
- ATP7B-like
- ATPase, Cu(2+)-transporting, beta polypeptide
- copper-transporting ATPase 2-like
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