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Ataxin 1 蛋白

(Ataxin 1 (ATXN1))
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010].

10 results :

custom-made ATXN1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7556164
 
custom-made ATXN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7552542
 
ATXN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Pubmed 1 reference
产品编号 ABIN1346189
 
ATXN1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant WB, SDS, ELISA
产品编号 ABIN7575091
 
ATXN1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % WB, SDS, Imm, PC
产品编号 ABIN7390679
 
ATXN1 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % WB, SDS, Imm, PC
产品编号 ABIN7415551
 
custom-made ATXN1 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, SDS, ELISA
产品编号 ABIN3119805
 
custom-made ATXN1 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, SDS, ELISA
产品编号 ABIN3089722
 
ATXN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2715013
 
ATXN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2715012
 
  • 类型 Protein
    • Protein
  • 应用范围
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • ELISA
    • Antibody Production (AbP)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • 适用
    • Human
    • Mouse
  • 论文引用
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • 抗原表位
    • AA 1-791
    • AA 1-815
    • AA 331-587
    • AA 569-807
    • AA 576-675
    • Transcript Variant 1
    • Transcript Variant 2
  • 标记
    • His tag
    • Myc-DYKDDDDK Tag
    • Strep Tag
    • GST tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Latest Publications for our Ataxin 1 蛋白

Yoon, Abdelmohsen, Kim, Yang, Martindale, Tominaga-Yamanaka, White, Orjalo, Rinn, Kreft, Wilson, Gorospe: "Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination." in: Nature communications, Vol. 4, pp. 2939, (2013) (PubMed).

Aliases for Ataxin 1 蛋白

ataxin 1 (ATXN1) 蛋白
ataxin 1b (atxn1b) 蛋白
ataxin 1 (Atxn1) 蛋白
Ataxin 1 (Atx-1) 蛋白
2900016G23Rik 蛋白
ataxin 1b 蛋白
ATX1 蛋白
Atx1 蛋白
ATXN1 蛋白
atxn1 蛋白
C85907 蛋白
CG4547 蛋白
D6S504E 蛋白
dAtx-1 蛋白
dAtx1 蛋白
Dmel\\CG4547 蛋白
ENSMUSG00000074917 蛋白
Gm10786 蛋白
SCA1 蛋白
Sca1 蛋白
sca1 蛋白
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