This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008].
Gubin, Njoroge, Wojda, Pack, Rios, Reid, Miller: "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family." in: Blood, Vol. 96, Issue 7, pp. 2621-7, (2000) (PubMed).