This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008].
Kanda, Stambolian, Chen, Curcio, Abecasis, Swaroop: "Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina." in: Molecular vision, Vol. 16, pp. 1317-23, (2010) (PubMed).