Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Rosman, Phukan, Huang, Pasche: "TGFBR1*6A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation." in: Cancer research, Vol. 68, Issue 5, pp. 1319-28, (2008) (PubMed).
Burbelo, Finegold, Kozak, Yamada, Takami: "Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene." in: Biochimica et biophysica acta, Vol. 1443, Issue 1-2, pp. 203-10, (1999) (PubMed).
Burbelo, Miyamoto, Utani, Brill, Yamada, Hall, Yamada: "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking." in: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 30919-26, (1996) (PubMed).