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抗Human CYLD 抗体:
抗Mouse (Murine) CYLD 抗体:
抗Rat (Rattus) CYLD 抗体:
Mouse (Murine) Polyclonal CYLD Primary Antibody for ELISA, WB - ABIN188848
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. in Cell 2006
Cow (Bovine) Polyclonal CYLD Primary Antibody for ICC, IF - ABIN410065
Wu, Mu, Gao, Wang, Sy, Li: Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. in The Journal of biological chemistry 1970
Human Polyclonal CYLD Primary Antibody for ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. in Infection and immunity 2010
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (显示 EGFR 抗体) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (显示 EGFR 抗体) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (显示 NFKB1 抗体) signaling, miR (显示 MLXIP 抗体)-130b can in return sustain the persistent activation of NF-kappaB (显示 NFKB1 抗体), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (显示 F2 抗体)-mediated MALT1 (显示 MALT1 抗体) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (显示 MLXIP 抗体)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
SPATA2 (显示 SPATA2 抗体) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (显示 RNF31 抗体) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
The data reveal SPATA2 (显示 SPATA2 抗体) as a high-affinity binding partner of CYLD and HOIP (显示 RNF31 抗体), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (显示 NFKB1 抗体) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (显示 TRAF3 抗体) (tumor necrosis factor (显示 TNF 抗体) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (显示 TRAF3 抗体) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (显示 STAT3 抗体) and miR (显示 MLXIP 抗体)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (显示 HDAC6 抗体) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
TLR4 (显示 TLR4 抗体) activates CASPASE-8 (显示 CASP8 抗体) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (显示 RNF138 抗体)- and RIPK1 (显示 RIPK1 抗体)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (显示 NOX4 抗体) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (显示 MYD88 抗体)-mediated signaling by directly interacting with MyD88 (显示 MYD88 抗体) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (显示 MYD88 抗体) at lysine 231.
CYLD interrupts the ERK (显示 EPHB2 抗体)- and p38 (显示 CRK 抗体)-/AP-1 (显示 JUN 抗体) and c-Myc (显示 MYC 抗体) pathways to suppress Nrf2 (显示 NFE2L2 抗体)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (显示 DNMT1 抗体)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (显示 DNMT1 抗体)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog