Multiclonal Antibodies

Multiclonal antibodies are unique blends of defined monoclonal antibodies that target multiple epitopes on the same antigen. This design enhances detection sensitivity and signal amplification, while maintaining high specificity and batch consistency. Discover high quality multiclonals from antibodies-online for targets like IgG, E-cadherin, NCAM1 or PECAM1. Our multiclonal antibodies are available with OTTO-fluorophore conjugates, offering bright, stable fluorescence and compatibility with multiplexed imaging and high-throughput cytometry workflows.

What are Multiclonal Antibodies?

Multiclonal antibodies are a defined mixture of carefully selected recombinant monoclonal antibodies, each designed to recognize a different epitope on the same antigen. This controlled combination delivers the broad epitope coverage and high sensitivity of polyclonal antibodies, while maintaining the specificity, reproducibility, and batch-to-batch consistency of recombinant monoclonals. By targeting multiple epitopes simultaneously, multiclonal antibodies are ideal for detecting low-abundance proteins, identifying multiple post-translational modifications, and serving as a reliable, consistent alternative to traditional polyclonals.

What are Advantages of Multiclonal Antibodies?

• Broader epitope coverage: The monoclonal mix recognizes multiple epitopes.
• Enhanced sensitivity: Multiple epitope recognition strengthens detection, ideal for low abundance targets.
• High specificity & consistency: Defined clone composition ensures reproducibility and reduces batch-to-batch variability.
• Covers multiple species: On low homology targets between species, different monoclonals allow for reliable detection.
• Multi monoclonal approach enables multiple PTMs.

When to use Multiclonal Antibodies?

Multiclonals combine several monoclonal clones in a consistent ratio, thus covering a broader range of epitopes than single monoclonals. Their respective epitope binding sites do not compete with each other. The result is higher affinity binding and improved signal strength without the variability typically seen in traditional polyclonals. Multiclonals are therefore an ideal solution for secondary antibody applications where a polyclonal antibody would traditionally be used. They they provide the coverage of polyclonals, combined with specificity and reproducibility only available from a recombinant antibody.

Multiclonal antibodies offer broad utility across the life science and pharmaceutical industries, delivering high sensitivity and reproducibility in a variety of applications. In biomarker detection by ELISA, they enable precise quantification of analytes in serum or culture media, even at low concentrations. In flow cytometry (FACS), their ability to recognize multiple epitopes enhances signal detection, making them particularly valuable for phenotyping rare or low-abundance cell populations and for use in multiplex panels. For Western blotting, multiclonals ensure robust detection across protein isoforms or post-translationally modified variants, while in immunohistochemistry (IHC) and immunofluorescence, they excel at identifying targets in complex tissue environments with variable expression. In pharmaceutical process development and quality control, their consistent performance supports reliable monitoring of critical antigens in bioprocess samples, ensuring data integrity throughout research and production workflows. Discover our range of high quality multiclonal antibodies down below!