PPP2R4 抗体
Quick Overview for PPP2R4 抗体 (ABIN969557)
抗原
See all PPP2R4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PPP2R4 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human PPP2R4 expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal." in: Stem cells (Dayton, Ohio), Vol. 28, Issue 5, pp. 874-84, (2010) (PubMed).
: "Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT." in: Molecular biology of the cell, Vol. 21, Issue 6, pp. 1140-52, (2010) (PubMed).
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: "Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal." in: Stem cells (Dayton, Ohio), Vol. 28, Issue 5, pp. 874-84, (2010) (PubMed).
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- PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))
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别名
- PPP2R4
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背景
- Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
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分子量
- 41 kDa
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基因ID
- 5524
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UniProt
- Q15257
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途径
- PI3K-Akt Signaling, M Phase, Hepatitis C, Toll-Like Receptors Cascades
抗原
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