PDX1 抗体
Quick Overview for PDX1 抗体 (ABIN969554)
抗原
See all PDX1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PDX1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human PDX1 expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Aberrant expression of TFF1, TFF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia." in: American journal of clinical pathology, Vol. 135, Issue 2, pp. 253-61, (2011) (PubMed).
: "Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis." in: Pancreas, Vol. 39, Issue 6, pp. 856-62, (2010) (PubMed).
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: "Aberrant expression of TFF1, TFF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia." in: American journal of clinical pathology, Vol. 135, Issue 2, pp. 253-61, (2011) (PubMed).
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- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
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别名
- PDX1
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背景
- The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
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分子量
- 30.8 kDa
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基因ID
- 3651
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UniProt
- P52945
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
抗原
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