PROZ 抗体
(2 references)Quick Overview for PROZ 抗体 (ABIN969368)
抗原
See all PROZ 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PROZ Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of PROZ expressed in E. Coli.
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亚型
- IgG1
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anti-Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) (AA 23-399) antibody
PROZ 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) (AA 1-400) antibodyPROZ 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) antibodyPROZ 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) (AA 1-400) antibodyPROZ 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ) (AA 220-340) antibodyPROZ 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).
: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." in: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).
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: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).
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- PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))
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别名
- PROZ
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背景
- PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
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分子量
- 45 kDa
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基因ID
- 8858
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UniProt
- P22891
抗原
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