PDPK1 抗体
(3 references)Quick Overview for PDPK1 抗体 (ABIN969347)
抗原
See all PDPK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PDK1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human PDK1 expressed in E. Coli.
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亚型
- IgG1
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anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pSer241) antibody
PDPK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 150-429) antibodyPDPK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 1-150) antibodyPDPK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 1-429) antibodyPDPK1 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 457-556) antibodyPDPK1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7E4G11 unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 524-556), (C-Term) antibodyPDPK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 83-338) antibodyPDPK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 457-556) antibodyPDPK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (pTyr373), (pTyr376) antibodyPDPK1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) (AA 277-556) antibodyPDPK1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells." in: Blood, Vol. 111, Issue 7, pp. 3723-34, (2008) (PubMed).
: "PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE." in: Nature cell biology, Vol. 10, Issue 2, pp. 127-37, (2008) (PubMed).
: "3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 12272-89, (2007) (PubMed).
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: "Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells." in: Blood, Vol. 111, Issue 7, pp. 3723-34, (2008) (PubMed).
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- PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
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别名
- PDK1
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背景
- Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. (provided by RefSeq). Tissue specificity: Expressed predominantly in the heart.
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分子量
- 44 kDa
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基因ID
- 5163
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UniProt
- Q15118
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途径
- PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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