NCOR1 抗体 (AA 1-192)
Quick Overview for NCOR1 抗体 (AA 1-192) (ABIN969310)
抗原
See all NCOR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-192
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原理
- NCOR1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1471-80, (2006) (PubMed).
: "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6404-14, (2005) (PubMed).
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Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1471-80, (2006) (PubMed).
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- NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))
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别名
- NCOR1
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背景
- NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
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基因ID
- 9611
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UniProt
- O75376
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途径
- Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process
抗原
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