KLHL13 抗体
(2 references)Quick Overview for KLHL13 抗体 (ABIN969245)
抗原
See all KLHL13 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- KLHL13 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human KLHL13 expressed in E. Coli.
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亚型
- IgG1
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anti-Kelch-Like 13 (KLHL13) (AA 1-260) antibody
KLHL13 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 13 (KLHL13) (N-Term) antibodyKLHL13 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 13 (KLHL13) (N-Term) antibodyKLHL13 适用: 人, 小鼠, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 13 (KLHL13) (N-Term) antibodyKLHL13 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).
: "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." in: Genome research, Vol. 14, Issue 9, pp. 1711-8, (2004) (PubMed).
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: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).
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- KLHL13 (Kelch-Like 13 (KLHL13))
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别名
- KLHL13
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背景
- KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
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分子量
- 74 kDa
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UniProt
- Q9P2N7
抗原
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