KDM3A 抗体
Quick Overview for KDM3A 抗体 (ABIN969228)
抗原
See all KDM3A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- KDM3A Antibody
-
纯化方法
- Ascitic fluid
-
免疫原
- Purified recombinant fragment of human KDM3A expressed in E. Coli.
-
亚型
- IgG1
-
-
-
-
应用备注
- ELISA: 1/10000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, (1999) (PubMed).
: "
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).
-
- KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))
-
别名
- KDM3A
-
背景
- This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and -ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
-
分子量
- 147 kDa
-
基因ID
- 55818
-
UniProt
- Q9Y4C1
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Warburg Effect
抗原
-