IHOG 抗体
This anti-IHOG antibody is a 小鼠 单克隆 antibody detecting IHOG in ELISA. Suitable for Drosophila melanogaster. This Primary Antibody has been cited in 1 publication.
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(1 reference)Quick Overview for IHOG 抗体 (ABIN969211)
抗原
See all IHOG 抗体
IHOG
(Interference Hedgehog (IHOG))
适用
Drosophila melanogaster
宿主
小鼠
克隆类型
单克隆
标记
This IHOG antibody is un-conjugated
应用范围
ELISA
克隆位点
3G8
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原理
- IHOG Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human IHOG expressed in E. Coli.
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亚型
- IgG1
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anti-Interference Hedgehog (IHOG) antibody
IHOG 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3G8 unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Structure of a heparin-dependent complex of Hedgehog and Ihog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).
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: "Structure of a heparin-dependent complex of Hedgehog and Ihog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).
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- IHOG (Interference Hedgehog (IHOG))
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别名
- IHOG
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背景
- The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
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分子量
- 98 kDa
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基因ID
- 33972
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UniProt
- Q9VM64
抗原
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