IGF1R-beta (AA 1101-1367) 抗体
(2 references)-
- 抗原
- IGF1R-beta
- 抗原表位
- AA 1101-1367
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
- 应用范围
- ELISA, Immunohistochemistry (IHC)
- 原理
- IGF1R-Beta Antibody
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.
- 克隆位点
- 3G5C1
- 亚型
- IgG2a
-
anti-IGF1R-beta antibody
适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3C8B1 unconjugated
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- 应用备注
- ELISA: 1/10000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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-
: "Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas." in: Carcinogenesis, Vol. 24, Issue 7, pp. 1225-31, (2003) (PubMed).
: "Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth ..." in: Molecular endocrinology (Baltimore, Md.), Vol. 17, Issue 9, pp. 1824-33, (2003) (PubMed).
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: "Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas." in: Carcinogenesis, Vol. 24, Issue 7, pp. 1225-31, (2003) (PubMed).
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- 抗原
- IGF1R-beta
- 背景
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Description: IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Aliases: IGF1R
- 分子量
- 96kDa
- 基因ID
- 3480
- HGNC
- 3480
- UniProt
- P08069
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