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HFE 抗体

Cited in 2+ publications. The 小鼠 单克隆 anti-HFE antibody (Clone 3F1) (ABIN969192) specifically detects HFE in ELISA 和 ICC. The antibody is reactive with 人 samples.
产品编号 ABIN969192
发货至: 中国
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北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HFE 抗体 (ABIN969192)

抗原

See all HFE 抗体
HFE (Hemochromatosis (HFE))

适用

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宿主

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小鼠

克隆类型

  • 50
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单克隆

标记

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This HFE antibody is un-conjugated

应用范围

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ELISA, Immunocytochemistry (ICC)

克隆位点

3F1
  • 原理

    HFE Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human HFE expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Hosgood, Menashe, He, Chanock, Lan: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).

    Valenti, Girelli, Valenti, Castagna, Como, Campostrini, Rametta, Dongiovanni, Messa, Fargion: "HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 4, Issue 8, pp. 1331-7, (2009) (PubMed).

  • 抗原

    HFE (Hemochromatosis (HFE))

    别名

    HFE

    背景

    The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. 

    分子量

    40 kDa

    UniProt

    Q30201

    途径

    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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