HDAC4 抗体
Quick Overview for HDAC4 抗体 (ABIN969190)
抗原
See all HDAC4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HDAC4 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human HDAC4 expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS containing 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX." in: Nucleic acids research, Vol. 38, Issue 9, pp. 2813-24, (2010) (PubMed).
: "Novel structural insights into class I and II histone deacetylases." in: Current topics in medicinal chemistry, Vol. 9, Issue 3, pp. 235-40, (2009) (PubMed).
: "14-3-3 regulates the nuclear import of class IIa histone deacetylases." in: Biochemical and biophysical research communications, Vol. 377, Issue 3, pp. 852-6, (2008) (PubMed).
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: "Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX." in: Nucleic acids research, Vol. 38, Issue 9, pp. 2813-24, (2010) (PubMed).
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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别名
- HDAC4
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背景
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
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分子量
- 119 kDa
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基因ID
- 9759
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UniProt
- P56524
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
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