HDAC3 抗体 (AA 224-428)
Quick Overview for HDAC3 抗体 (AA 224-428) (ABIN969188)
抗原
See all HDAC3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 224-428
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原理
- HDAC3 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.
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亚型
- IgG2a
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应用备注
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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HDAC3 overexpression and colon cancer cell proliferation and differentiation." in: Molecular carcinogenesis, Vol. 47, Issue 2, pp. 137-47, (2008) (PubMed).
: "Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2." in: Molecular and cellular biology, Vol. 27, Issue 4, pp. 1280-95, (2007) (PubMed).
: "Elevated and deregulated expression of HDAC3 in human astrocytic glial tumours." in: Folia biologica, Vol. 52, Issue 1-2, pp. 21-33, (2006) (PubMed).
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HDAC3 overexpression and colon cancer cell proliferation and differentiation." in: Molecular carcinogenesis, Vol. 47, Issue 2, pp. 137-47, (2008) (PubMed).
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- HDAC3 (Histone Deacetylase 3 (HDAC3))
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别名
- HDAC3
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背景
- HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
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分子量
- 48.8 kDa
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基因ID
- 8841
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UniProt
- O15379
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途径
- Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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