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HDAC3 抗体 (AA 224-428)

This anti-HDAC3 antibody is a 小鼠 单克隆 antibody detecting HDAC3 in WB, ELISA 和 ICC. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN969188
发货至: 中国

Quick Overview for HDAC3 抗体 (AA 224-428) (ABIN969188)

抗原

See all HDAC3 抗体
HDAC3 (Histone Deacetylase 3 (HDAC3))

适用

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宿主

  • 98
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  • 1
小鼠

克隆类型

  • 96
  • 28
单克隆

标记

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This HDAC3 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

克隆位点

7G6C5
  • 抗原表位

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    AA 224-428

    原理

    HDAC3 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.

    亚型

    IgG2a
  • 应用备注

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: "HDAC3 overexpression and colon cancer cell proliferation and differentiation." in: Molecular carcinogenesis, Vol. 47, Issue 2, pp. 137-47, (2008) (PubMed).

    Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: "Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2." in: Molecular and cellular biology, Vol. 27, Issue 4, pp. 1280-95, (2007) (PubMed).

    Libý, Kostrouchová, Pohludka, Yilma, Hrabal, Sikora, Brozová, Kostrouchová, Rall, Kostrouch: "Elevated and deregulated expression of HDAC3 in human astrocytic glial tumours." in: Folia biologica, Vol. 52, Issue 1-2, pp. 21-33, (2006) (PubMed).

  • 抗原

    HDAC3 (Histone Deacetylase 3 (HDAC3))

    别名

    HDAC3

    背景

    HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

    分子量

    48.8 kDa

    基因ID

    8841

    UniProt

    O15379

    途径

    Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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